Stroke and lipid profile in a cardiovascular risk program of Armenia, Quindío
DOI:
https://doi.org/10.33975/riuq.vol34nS4.1027Keywords:
Stroke, Cholesterol, Cholesterol-HDL, TriglyceridesAbstract
Objective: To describe the lipid profile in patients with stroke in a cardiovascular risk program in a first-level health institution in Armenia, Quindío during 2018.
Methods: A cross-sectional descriptive study was carried out with a sample of 300 people in a population of a first-level service provider institution with diagnosis or history of stroke. Variables were described in average, standard deviation and confidence intervals, a comparative analysis was made by sex. Variance analysis and square Chi were performed. A relationship of the lipid profile variables with the diagnosis and history of stroke was established. A value of p<0.05 was considered for statistically significant differences.
Results: We found a prevalence of stroke in the population at the first level of care of 2.7%, and a statistically significant relationship between the low value of HDL and the antecedent of stroke (p=0.024 value) and the diagnosis of stroke with high TG (p=0.041 value).
Conclusions: The literature describes LDL as a factor highly related to the development of LCA, However, the present study found that there is a statistically significant relationship between the diagnosis of LCA with high TG and the history of LCA with low HDL levels, these 2 conditions have been found to be prevalent in this CVR population.
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Ruiz A, Pérez G, Ángel M. Ataque cerebrovascular isquémico: fisiopatología desde el sistema biomédico y su equivalente en la medicina tradicional china. Rev FacMed.2017; 65(1):137-44. DOI: https://doi.org/10.15446/revfacmed.v65n1.57508
Silva F, Zarruk J, Quintero C, Arenas W, Rueda-Clausen C, Silva S. et al. Enfermedad cerebrovascular en Colombia. RevCol Cardiol. 2006; 13(2):85-9.
World Health Organization: Stroke 1989. Recommendations on stroke prevention, diagnosis and theraphy: Report of the WHO Task Force on Stroke and other cerebrovascular disorders. Stroke. 1989; 20(10):1407-31.
O´Donnell M, Chin S, Rangarajan S, et al. Global and regional effects of potentially modiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study. The Lancet. 2016 388 (10046), 761-775. DOI:http://dx.doi.org/10.1016/S0140-6736(16)30506-2
Villarreal E, Forero Y, Poveda E, Baracaldo C, López E. Marcadores de riesgo Cardiovascular en escolares de cinco departamentos de la región oriental en Colombia. Biomédica. 2008; 28(1):38-49.
https://doi.org/10.7705/biomedica.v28i1.107
Ricart C, Leno C, Altable M, Rebollo M. Factores de riesgo de los accidentes cerebrovasculares. Etiopatogenia del accidente cerebrovascular. Medicine. 2003; 8(91):4911-17. DOI: 10.1016/S0304-5412(03)70911-1
Yu H, Huang Y, Chen X, Nie W, Wang Y, Jiao J, et al. High-sensitivity C-reactive protein in stroke patients – The importance in consideration of influence of multiple factors in the predictability for disease severity and death. JClinNeurosci.2017; 36:12-9.https://DOI.org/10.1016/j.jocn.2016.10.020
Wang A, Cui Y, Meng X, Su Z, Cao Y, Yang Y, Liu C, et al. The relationship between oxidized low-density lipoprotein and the NIHSS score among patients with acute ischemic stroke: the SOS-Stroke Study. Atherosclerosis. 2018; 270:21-5. DOI: 10.1016/j.atherosclerosis.2018.01.028
Wang A, Yang Y, Su Z, Yue W, Hao H, Ren L, et al.Association of oxidized low-density lipoprotein with prognosis of stroke and stroke subtypes. Stroke. 2017; 48(1):91-7. DOI: 10.1161/strokeaha.116.014816.
Canalizo E, Favela E, Salas J, Gómez R, Jara R, Torres L, et al. Guía de práctica clínica: diagnóstico y tratamiento de las dislipidemias. Rev Med Inst Mex Seguro Soc. 2013; 51(6):700-9.
Disponible en: http://www.redalyc.org/articulo.oa?id=457745492020
Shie F, Neely M, Maezawa I, Wu H, Olson S, Jürgens G, et al. Oxidized low-density lipoprotein is present in astrocytes surrounding cerebral infarcts and stimulates astrocyte interleukin-6 secretion. Am J Pathol. 2004; 164(4):1173-81. DOI: https://doi.org/10.1016/S0002-9440(10)63205-1
Palacios E, Triana J, Gómez A, Quiñones M. Ataque cerebrovascular isquémico: caracterización demográfica y clínica hospital de San José de Bogotá dc, 2012-2013. Repert med cir. 2014; 23(2):127-33. Disponible en:
https://revistas.fucsalud.edu.co/index.php/repertorio/article/view/727
Global Burden of Disease Stroke Collaborators. Global, regional, and national burden of stroke, 1990–2016. A systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019; 18(5):439-58. DOI:https://doi.org/10.1016/S1474-4422(19)30034-1
Pradilla G, Roselli D, Bautista L, et al. Estudio Neuroepidemiológico Nacional (EPINERURO) colombiano. Acta Med Colomb 1998; 23: 258.
Secretaría de Salud de Armenia, Quindío. Bodega Integrada de Datos - SISPRO-MSPS. Disponible en: www.quindio.gov.co
Mendis S, Puska P, Norrving B. Global Atlas on cardiovascular disease prevention and control. World Health Organization, World Heart Federation, World Stroke Organization. Geneva 2011.
Disponible en: http://www.who.int/iris/handle/10665/44701.
Rodríguez J, Ruiz F, Peñaloza E, Eslava J, Gómez L, Sánchez H, et al. Encuesta Nacional de Salud ENS 2007. Ministerio de la Protección Social, Colombia. 2007. Disponible en:
Virani S, Alonso A, Benjamin E, Bittencourt M, Callaway C, Carson A,et al. Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association. Circulation. 2020;141:e139-e596.https://doi.org/10.1161/CIR.0000000000000757
Galvis Y, Barona J, Cardona J. Prevalencia de dislipidemias en una institución prestadora de servicios de salud de Medellín (Colombia) 2013. Rev CES Med. 2016; 30(1):3-13. DOI: http://dx.doi.org/10.21615/cesmedicina.30.1.1
Álvarez J, Carvajal W, Serna J, Duque J, Nieto O. Tasa de filtración glomerular en una población de riesgo cardiovascular. Sociedad Colombiana de nefrología e hipertensión. Permanier México S.A. Nefro Latinoam. 2018; 15:40-6. DOI:10.24875/NEFRO.1800001.
Análisis de situación de salud en el modelo de determinantes sociales en salud departamento del Quindío 2018. Secretaría de salud departamental del Quindío. Gobernación del Quindío.2018. Disponible en: https://quindio.gov.co/home/docs/items/item_196/salud_publica/ASIS_DEPARTAMENTO_QUINDIO_2018.pdf
Fondo Colombiano de Enfermedades de Alto Costo. Cuenta de Alto Costo (CAC). República de Colombia, Ministerio de Salud y protección social – Ministerio de hacienda y crédito público. Situación de la enfermedad renal crónica, la hipertensión arterial y la diabetes mellitus en Colombia 2017. Disponible en:
Yaghi S, Elkind M. Lipids and cerebrovascular disease: Research and practice. Stroke. 2015; 46(11):3322-8. DOI:10.1161/STROKEAHA.115.011164
Labreuche J, Deplanque D, Touboul P, Bruckert E, Amarenco P. Association between change in plasma triglyceride levels and risk of stroke and carotid atherosclerosis: Systematic review and meta-regression analysis. Atherosclerosis. 2010; 212:9-15. DOI:10.1016/j.atherosclerosis.2010.02.011
Wieberdink R, Poels M, Vernooij M, Koudstaal P, Hofman A, Van der Lugt A, et al. Serum lipid levels and the risk of intracerebral hemorrhage: The Rotterdam study. Arterioscler Thromb Vasc Biol. 2011;31:2982-9.DOI:10.1161/ATVBAHA.111.234948
Bonaventure A, Kurth T, Pico F, Barberger P, Ritchie K, Stapf C. Triglycerides and risk of hemorrhagic stroke vs. Ischemic vascular events: The three-city study. Atherosclerosis. 2010; 210:243-8. DOI:10.1016/j.atherosclerosis.2009.10.043
Zheng J, Sun Z, Zhang X, Li Z, Guo X, Xie Y, et al. Non-traditional lipid profiles associated with ischemic stroke not hemorrhagic stroke in hypertensive patients: results from an 8.4 years follow-up study. Lipids Health Dis. 2019;18(1):9. DOI:10.1186/s12944-019-0958-y
Freiberg J, Tybjaerg A, Jensen J, Nordestgaard B. Nonfasting triglycerides and risk of ischemic stroke in the general population.JAMA.2008;300(18):2142-52. DOI:10.1001/jama.2008.621
Amarenco P, Goldstein L, Callahan A, Sillesen H, Hennerici M, O’Neill B, et al; SPARCL Investigators. Baseline blood pressure, low- and high-density lipoproteins, and triglycerides and the risk of vascular events in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial. Atherosclerosis.2009; 204(2):515-20. DOI:10.1016/j.atherosclerosis.2008.09.008
Glasser S, Mosher A, Banach M, Howard G. What is the association of lipid levels and incident stroke?. Int J Cardiol. 2016; 220:890-4. DOI:10.1016/j.ijcard.2016.06.091
Wu J, Chen S, Liu L, Gao X, Zhou Y, Wang C, et al. Non-high-density lipoprotein cholesterol vs low-density lipoprotein cholesterol as a risk factor for ischemic stroke: a result from the Kailuan study. Neurol Res.2013;35(5):505-11. DOI:10.1179/1743132813y.0000000206
Kurth T, Everett B, Buring J, Kase C, Ridker P, Gaziano J. Lipid levels and the risk of ischemic stroke in women. Neurology. 2007; 68(8):556-62.DOI:10.1212/01.wnl.0000254472.41810.0d
Cziraky M, Watson K, Talbert R. Targeting lowHDL-cholesterol to decrease residual cardiovascular risk in the managed care setting.J Manag Care Pharm.2008;14(8s):S1-31. DOI:10.18553/jmcp.2008.14.s8-a.1
Nieto O, Zárate M, Landázuri P. Ejercicio y redes fisiológicas y bioquímicas en la hipertensión. Acta Bioquim Clin Latinoam. 2015;49(4):383-92.Disponible en: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572015000400002&lng=es
Nieto O, García D, Jiménez J, Landázuri P. Efecto del ejercicio en subpoblaciones de lipoproteínas de alta densidad y en la presión arterial. Rev Salud Pública. 2013;15(1):12-22.Disponible en:
https://revistas.unal.edu.co/index.php/revsaludpublica/article/view/37297
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